Primary bronchogenic carcinoma associated with emphysematous giant bulla.

Operations for emphysematous giant bulla have been performed on 17 patients. Complications of primary lung cancer were observed in four of the 17 patients. All the patients who had such lung cancer were male and heavy smokers. As to histological type, squamous cell carcinoma were found in three patients and undifferentiated cancer of large cell type in one patient. The three had squamous cell carcinoma generated from the bronchus on the central side of the giant bulla, while the large cell carcinoma ' observed in one patient was generated from the bronchus close to the bulla. In two patients, cancer was generated while bulla was under observation, In one patient, the generation of cancer was found simultaneously with the bulla discovery. In the other patient, cancer was generated after bullectomy. These findings suggest that physicians should always pay careful attention to generation and complication of cancer while treafing giant bulla 577